A security guard was stabbed and three other security guards received minor injuries while trying to kick a group out of a licenced premises, after they were involved in a fight, NT Police said.

Police communications director Mark Wilton said in a statement that about 2:50am Tuesday, police received reports of a fight involving three men and one woman at a Gilruth Avenue licenced premises described as being in Darwin city.

He said the group were allegedly refused service and escorted out of the premises by security officers, when they began assaulting security.

One security guards suffered a serious stab wound to the arm and was treated at Royal Darwin Hospital, Mr Wilton said, while three other security guards suffered minor injuries.

Mr Wilton said the group drove off in a Mitsubishi Outlander.

The only late-night licenced premises with an address on Gilruth Avenue is the Mindil Beach Casino Resort.

Police are asking anyone who witnessed the assaults to call 131 444, or report it anonymously through Crime Stoppers on 1800 333 000.