A 21-year-old man has been charged with murder after allegedly running over a man in Timber Creek on Monday night, amid a massive brawl in the community that also saw two other people stabbed and taken to hospital.

The mayhem occurred around 8:50pm Monday night, when police received reports that a large group of people were fighting along the Victoria Highway in Timber Creek, about 600km southwest of Darwin.

During the melee, a man started driving a vehicle dangerously through the area before striking and killing a 27-year-old male, police said.

Two others, including a 16-year-old boy and a 65-year-old woman, were reportedly stabbed during the incident.

“Investigations remain ongoing into the circumstances of the related stabbings during the incident,” police media director Mark Wilton said in a statement on Thursday.

“The two victims remain in hospital in a serious but stable condition.”

NT Police said the 21-year-old has been remanded and charged with murder and will face Katherine Local Court on Friday, November 7.

No other charges in connection to the disturbance have been laid.

“Police continue to urge anyone with information about the incident to make contact on 131 444 quoting reference number NTP2500109691,” Mr Wilton said.

“Anonymous reports can be made through Crime stoppers on 1800 333 000 or via https://crimestoppersnt.com.au/.”