A man died after a collision between two cars in Alice Springs on Wednesday night, with alcohol and distraction believed to have contributed to the crash, NT Police said.

Police director of communications Mark Wilton said in a statement that about 10:20pm there was a collision on South Terrace, The Gap, between a Holden Commodore carrying two men and a woman, and a Nissan Micra carrying a man.

He said a 54-year-old man in the Holden died at the scene, while a 44-year-old woman was in a serious but stable condition.

Police suspect intoxication and distraction are contributing factors in the crash, Mr Wilton said.

Major Crash Investigation Unit detectives are looking for witnesses who were in the area of South Terrace and Benstead St, The Gap, at that time. Police are also looking for dash cam or CCTV footage. You can call police on 131 444, or alternatively Crime Stoppers on 1800 333 000.